diethyl[2-[2-(1-naphthylmethyl)-3-(tetrahydro-2-furyl)propionyloxy]ethyl]ammonium hydrogen oxalate
nafronyl oxalate
CAS: 3200-06-4
Molecular Formula: C26H35NO7
diethyl[2-[2-(1-naphthylmethyl)-3-(tetrahydro-2-furyl)propionyloxy]ethyl]ammonium hydrogen oxalate - Names and Identifiers
| Name | nafronyl oxalate |
| Synonyms | ls121 eu-1806 CLARANTIN nafronyl oxalate naftidrofuryloxalate Nafronyl acid oxalate Naftidrofuryl oxalate naftidrofuryl hydrogen oxalate 2-(diethylamino)ethyltetrahydro-alpha-(1-naphthylmethyl)-2-furanpropionateo 2-(diethylamino)ethyl 3-(naphthalen-1-yl)-2-(tetrahydrofuran-2-ylmethyl)propanoate alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate diethyl-[2-[2-(1-naphthylmethyl)-3-tetrahydrofuran-2-yl-propanoyl]oxyethyl]ammonium, oxalate diethyl[2-[2-(1-naphthylmethyl)-3-(tetrahydro-2-furyl)propionyloxy]ethyl]ammonium hydrogen oxalate |
| CAS | 3200-06-4 |
| EINECS | 221-703-0 |
| InChI | InChI=1/C24H33NO3.C2H2O4/c1-3-25(4-2)14-16-28-24(26)21(18-22-12-8-15-27-22)17-20-11-7-10-19-9-5-6-13-23(19)20;3-1(4)2(5)6/h5-7,9-11,13,21-22H,3-4,8,12,14-18H2,1-2H3;(H,3,4)(H,5,6)/p-1 |
diethyl[2-[2-(1-naphthylmethyl)-3-(tetrahydro-2-furyl)propionyloxy]ethyl]ammonium hydrogen oxalate - Physico-chemical Properties
| Molecular Formula | C26H35NO7 |
| Molar Mass | 473.56 |
| Density | 1.2205 (rough estimate) |
| Melting Point | 110-111° |
| Boling Point | 574°C (rough estimate) |
| Flash Point | 355.6°C |
| Solubility | Freely soluble in water, freely soluble or soluble in ethanol (96 per cent), slightly or sparingly soluble in acetone. |
| Vapor Presure | 1.48E-18mmHg at 25°C |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.6000 (estimate) |
| In vitro study | Naftidrofuryl oxalate (Nafronyl oxalate salt) may be effective for relieving the pain of muscle cramps. Naftidrofuryl oxalate (Nafronyl oxalate salt) is the only vasoactive drug for peripheral arterial disease (PAD) which is likely to be cost-effective. Naftidrofuryl oxalate (Nafronyl oxalate salt) is ranked first for both maximum walking distance (MWD) and pain-free walking distance (PFWD) (probability of 0·947 and 0·987, respectively, of being the best treatment) followed by cilostazol and pentoxifylline. Naftidrofuryl oxalate (Nafronyl oxalate salt) is effective treatments for claudication, Naftidrofuryl oxalate is likely to be the most effective, with minimal serious adverse events. |
diethyl[2-[2-(1-naphthylmethyl)-3-(tetrahydro-2-furyl)propionyloxy]ethyl]ammonium hydrogen oxalate - Risk and Safety
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | LU5805000 |
| HS Code | 29321900 |
| Toxicity | LD50 oral in rat: 711mg/kg |
diethyl[2-[2-(1-naphthylmethyl)-3-(tetrahydro-2-furyl)propionyloxy]ethyl]ammonium hydrogen oxalate - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.112 ml | 10.558 ml | 21.117 ml |
| 5 mM | 0.422 ml | 2.112 ml | 4.223 ml |
| 10 mM | 0.211 ml | 1.056 ml | 2.112 ml |
| 5 mM | 0.042 ml | 0.211 ml | 0.422 ml |
Last Update：2024-01-02 23:10:35
diethyl[2-[2-(1-naphthylmethyl)-3-(tetrahydro-2-furyl)propionyloxy]ethyl]ammonium hydrogen oxalate - Nature
| solubility | Freely soluble in water, freely soluble or soluble in ethanol (96 per cent), slightly or sparingly soluble in acetone. |
Last Update：2024-04-10 22:29:15
diethyl[2-[2-(1-naphthylmethyl)-3-(tetrahydro-2-furyl)propionyloxy]ethyl]ammonium hydrogen oxalate - Uses and synthesis methods
overview
Naphfururamide ester oxalate is an organic acid substance, which is a dilator of cerebral blood vessels and peripheral blood vessels; it antagonizes the effects of serotonin and bradykinin; it can increase intracellular ATP to improve cell metabolism; Reduce the viscosity and fibrinogen concentration of blood and plasma; increase the oxidative ability of cells, and have a protective effect on cell hypoxia; in addition, it has papaverine-like antispas.
pharmacological action
naphfururamide oxalate is a drug used to treat cardiovascular and cerebrovascular diseases and peripheral vascular diseases. It has the following characteristics: its dilation effect is stronger than niacin, and the effect of enhancing cerebrovascular flow is slower and longer than poppy. It is believed that its clinical application is safer than papaverine, and its curative effect on severe lower limb arteritis is more significant and rapid than nicotinamide hydroxypropylline.
application
naphfururamide ester oxalate is a drug used to treat cardiovascular and cerebrovascular diseases and peripheral vascular diseases. It has the following characteristics: its expansion effect is stronger than niacin, and the effect of enhancing cerebrovascular flow is slower and longer than poppy.
biological activity
Naftidrofuryl oxalate (Nafronyl oxalate salt) is a drug used in the management of peripheral blood and cerebrovascular diseases such as vasodilators, which increases cell oxidative capacity and is a 5-HT2 receptor antagonist.
target
Target Value
5-HT2 receptor
in vitro study
Naftidrofuryl oxalate (Nafronyl oxalate salt) may be effective for relieving the pain of muscle cramps.
Naftidrofuryl oxalate (Nafronyl oxalate salt) is the only vasoactive drug for peripheral arterial disease (PAD) which is likely to be cost-effective.
Naftidrofuryl oxalate (Nafronyl oxalate salt) is ranked first for both maximum walking distance (MWD) and pain-free walking distance (PFWD) (probability of 0·947 and 0·987, respectively, of being the best treatment) followed by cilostazol and pentoxifylline. Naftidrofuryl oxalate (Nafronyl oxalate salt) is effective treatments for claudication, Naftidrofuryl oxalate is likely to be the most effective, with minimal serious adverse events.
Last Update：2024-04-10 22:29:15
diethyl[2-[2-(1-naphthylmethyl)-3-(tetrahydro-2-furyl)propionyloxy]ethyl]ammonium hydrogen oxalate - Reference Information
| overview | nafuroxide oxalate is an organic acid substance, which is a dilator of cerebral blood vessels and peripheral blood vessels; antagonize the effects of serotonin and bradykinin; it can increase intracellular ATP to improve cell metabolism; reduce blood and plasma viscosity and fibrinogen concentration; it increases the oxidation ability of cells and has a protective effect on cell hypoxia; in addition, it has papaverine-like antispasmodic effect, which is slow and long-lasting. |
| pharmacological action | nafuramide oxalate is a drug used to treat cardiovascular and cerebrovascular and peripheral vascular diseases. it has the following characteristics: its expansion effect is stronger than nicotinic acid, and its effect on enhancing cerebrovascular flow is slower and longer than that of poppy. It is believed that its clinical application is safer than papaverine, and its curative effect on severe lower limb arteritis is significantly and faster than that of nicotinamide hydroxypropylline. |
| application | naphfluroxide oxalate is a drug used to treat cardiovascular and peripheral vascular diseases. It has the following characteristics: its expansion effect is stronger than niacin, and the effect of enhancing cerebrovascular flow is slower and longer than poppy. |
| biological activity | Naftidrofuryl oxalate (Nafronyl oxalate salt) is a drug used in the management of peripheral blood and cerebrovascular diseases such as vasodilators, which increases cell oxidation and is a 5-HT2 receptor antagonist. |
| target | TargetValue 5-HT2 receptor () |
| Target | Value |
| in vitro study | Naftidrofuryl oxalate (Nafronyl oxalate) may be effective for relieving the pain of muscle oxalate (Nafronyl oxalate) is the only vasoactive drug for peripheral arterial disease (PAD) which is like to be cost-effective. Naftidrofuryl Naftidrofuryl (Nafronyl oxalate) is rank first for both maximum walking distance (MWD) and pain-free walking distance (PFWD) (probability of 0 · 947 and 0 · 987, respectively, of being the best treatment) followed by cilostazol and pentoxifylline. Naftidrofuryl oxalate (Nafronyl oxalate salt) is effective treatments for claudication, Naftidrofuryl oxalate is like to be the most effective, with minimal serious adverse events. |
Last Update：2024-04-09 20:52:54
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Product Name: alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate Visit Supplier Webpage Request for quotation
CAS: 3200-06-4
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
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CAS: 3200-06-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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